RAN_HUMAN

Source: PM19886704
PM23856902
PM22954596
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: RAN , ARA24 , OK/SW-cl.81
Protein names and data: RAN_HUMAN , GTP-binding nuclear protein Ran , Androgen receptor-associated protein 24; GTPase Ran; Ras-like protein TC4; Ras-related nuclear protein Lenght: 216 a.a.
Mass: 24423 Da
fasta formatted sequence
Function: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2. Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.
Cellular location: Nucleus. Cytoplasm. Melanosome. Note=Predominantly nuclear during interphase (By similarity). Becomes dispersed throughout the cytoplasm during mitosis. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Tissue specificity: Expressed in a variety of tissues.

Genetic variants

Database cross-references

UniProt: P62826
Ensembl: ENST00000392369
Ensembl: ENST00000543796
MIM: 601179
neXtProt: NX_P62826
Antibodypedia: P62826 (may not find the protein thus also not any antibody)
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