RAP1A_HUMAN

Source: hRBCD ; ID: IPI00019345
PM19886704
PM23856902
BSc_CH
PM22954596
Marked as 'Membrane associated protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: RAP1A , KREV1
Protein names and data: RAP1A_HUMAN , Ras-related protein Rap-1A , C21KG; G-22K; GTP-binding protein smg p21A; Ras-related protein Krev-1; Flags: Precursor Lenght: 184 a.a.
Mass: 20987 Da
fasta formatted sequence
Function: Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions.
Cellular location: Cell membrane; Lipid-anchor. Cytoplasm. Cytoplasm, perinuclear region. Cell junction (By similarity). Early endosome (By similarity). Note=Recruited from early endosome to late endosome compartment after nerve growth factor (NGF) stimulation. Localized with RAPGEF2 at cell-cell junctions (By similarity). Colocalized with RAPGEF2 in the perinuclear region.

Database cross-references

UniProt: P62834
Ensembl: ENST00000356415
Ensembl: ENST00000369709
Ensembl: ENST00000436150
Ensembl: ENST00000545460
MIM: 179520
neXtProt: NX_P62834
Antibodypedia: P62834 (may not find the protein thus also not any antibody)
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