Source: hRBCD ; ID: IPI00015148
Marked as 'Membrane associated protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)

Gene names: RAP1B , OK/SW-cl.11
Protein names and data: RAP1B_HUMAN , Ras-related protein Rap-1b , GTP-binding protein smg p21B; Flags: Precursor Lenght: 184 a.a.
Mass: 20825 Da
fasta formatted sequence

Function: GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function.
Cellular location: Cell membrane. Cytoplasm, cytosol. Cell junction. Note=May shuttle between plasma membrane and cytosol. Presence of KRIT1 and CDH5 is required for its localization to the cell junction.

Database cross-references

UniProt: P61224
Ensembl: ENST00000250559
Ensembl: ENST00000341355
Ensembl: ENST00000393436
Ensembl: ENST00000450214
Ensembl: ENST00000537460
Ensembl: ENST00000539091
Ensembl: ENST00000540209
Ensembl: ENST00000542145
MIM: 179530
neXtProt: NX_P61224
Antibodypedia: P61224 (may not find the protein thus also not any antibody)
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