RAP2A_HUMAN

Source: PM19886704
PM23856902
BSc_CH
PM22954596
Marked as 'Membrane associated protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: RAP2A
Protein names and data: RAP2A_HUMAN , Ras-related protein Rap-2a , RbBP-30; Flags: Precursor Lenght: 183 a.a.
Mass: 20615 Da
fasta formatted sequence
Function: Small GTP-binding protein which cycles between a GDP- bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading.
Cellular location: Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Midbody. Note=May also localize to the Golgi (PubMed:7962206) and the gelatinase-containing granules of neutrophils (PubMed:8391995). Colocalizes with RASGEF1B to midbody at telophase (PubMed:23894443).

Database cross-references

UniProt: P10114
Ensembl: ENST00000245304
MIM: 179540
neXtProt: NX_P10114
Antibodypedia: P10114 (may not find the protein thus also not any antibody)
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