Source: PM19886704
Marked as 'Membrane associated protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)

Gene names: RAB11B , YPT3
Protein names and data: RB11B_HUMAN , Ras-related protein Rab-11B , GTP-binding protein YPT3; Flags: Precursor Lenght: 218 a.a.
Mass: 24489 Da
fasta formatted sequence

Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage- gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis.
Cellular location: Recycling endosome membrane; Lipid-anchor; Cytoplasmic side (By similarity). Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Lipid-anchor; Cytoplasmic side (By similarity). Cytoplasmic vesicle, phagosome membrane; Lipid- anchor; Cytoplasmic side (Probable). Note=Recruited to phagosomes containing S.aureus.

Database cross-references

UniProt: Q15907
Ensembl: ENST00000328024
MIM: 604198
neXtProt: NX_Q15907
Antibodypedia: Q15907 (may not find the protein thus also not any antibody)
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