RBBP7_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: RBBP7 , RBAP46
Protein names and data: RBBP7_HUMAN , Histone-binding protein RBBP7 , Histone acetyltransferase type B subunit 2; Nucleosome-remodeling factor subunit RBAP46; Retinoblastoma-binding protein 7; RBBP-7; Retinoblastoma-binding protein p46 Lenght: 425 a.a.
Mass: 47820 Da
fasta formatted sequence
Function: Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.
Cellular location: Nucleus.

Database cross-references

UniProt: Q16576
Ensembl: ENST00000380084
Ensembl: ENST00000380087
MIM: 300825
neXtProt: NX_Q16576
Antibodypedia: Q16576 (may not find the protein thus also not any antibody)
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