RBGPR_HUMAN

Source: PM19886704
PM23856902
PM22954596
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)

Gene names: RAB3GAP2 , KIAA0839
Protein names and data: RBGPR_HUMAN , Rab3 GTPase-activating protein non-catalytic subunit , RGAP-iso; Rab3 GTPase-activating protein 150 kDa subunit; Rab3-GAP p150; Rab3-GAP150; Rab3-GAP regulatory subunit Lenght: 1393 a.a.
Mass: 155985 Da
fasta formatted sequence

Function: Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3- GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non- synaptic vesicular release of neurotransmitters.
Disease:
Cellular location: Cytoplasm. Note=In neurons, it is enriched in the synaptic soluble fraction.
Tissue specificity: Ubiquitous.

Genetic variants

Database cross-references

UniProt: Q9H2M9
Ensembl: ENST00000358951
MIM: 212720
MIM: 609275
MIM: 614225
neXtProt: NX_Q9H2M9
Antibodypedia: Q9H2M9 (may not find the protein thus also not any antibody)
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