RBM38_HUMAN

Source: PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: RBM38 , RNPC1, SEB4
Protein names and data: RBM38_HUMAN , RNA-binding protein 38 , CLL-associated antigen KW-5; HSRNASEB; RNA-binding motif protein 38; RNA-binding region-containing protein 1; ssDNA-binding protein SEB4 Lenght: 239 a.a.
Mass: 25498 Da
fasta formatted sequence
Function: RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Isoform 1, but not isoform 2, has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2- IIIb, an epithelial cell-specific isoform of FGFR2. Plays a role in myogenic differentiation.
Cellular location: Cytoplasm, cytosol. Nucleus.

Genetic variants

Database cross-references

UniProt: Q9H0Z9
Ensembl: ENST00000356208
Ensembl: ENST00000440234
MIM: 612428
neXtProt: NX_Q9H0Z9
Antibodypedia: Q9H0Z9 (may not find the protein thus also not any antibody)
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