RBMX_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: RBMX , HNRPG, RBMXP1
Protein names and data: RBMX_HUMAN , RNA-binding motif protein, X chromosome , Glycoprotein p43; Heterogeneous nuclear ribonucleoprotein G; hnRNP G; RNA-binding motif protein, X chromosome, N-terminally processed Lenght: 391 a.a.
Mass: 42332 Da
fasta formatted sequence
Function: RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single- stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Plays also a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1- beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment.
Cellular location: Nucleus. Note=Component of ribonucleosomes. Localizes in numerous small granules in the nucleus.
Tissue specificity: Expressed strongly in oral keratinocytes, but only weakly detected in oral squamous cell carcinomas (at protein level).

Database cross-references

UniProt: P38159
Ensembl: ENST00000320676
Ensembl: ENST00000431446
MIM: 300199
neXtProt: NX_P38159
Antibodypedia: P38159 (may not find the protein thus also not any antibody)
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