RBP1_HUMAN

Source: PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: RALBP1 , RLIP1, RLIP76
Protein names and data: RBP1_HUMAN , RalA-binding protein 1; RalBP1 , 76 kDa Ral-interacting protein; Dinitrophenyl S-glutathione ATPase; DNP-SG ATPase; Ral-interacting protein 1 Lenght: 655 a.a.
Mass: 76063 Da
fasta formatted sequence
Function: Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin.
Cellular location: Membrane; Peripheral membrane protein.
Tissue specificity: Expressed ubiquitously but at low levels. Shows a strong expression in the erythrocytes.

Genetic variants

Database cross-references

UniProt: Q15311
Ensembl: ENST00000019317
Ensembl: ENST00000383432
MIM: 605801
neXtProt: NX_Q15311
Antibodypedia: Q15311 (may not find the protein thus also not any antibody)
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