RBX2_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: RNF7 , RBX2, ROC2, SAG
Protein names and data: RBX2_HUMAN , RING-box protein 2; Rbx2 , CKII beta-binding protein 1; CKBBP1; RING finger protein 7; Regulator of cullins 2; Sensitive to apoptosis gene protein Lenght: 113 a.a.
Mass: 12683 Da
fasta formatted sequence
Function: Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents.
Pathway: Protein modification; protein ubiquitination.
Cellular location: Cytoplasm. Nucleus.
Tissue specificity: Expressed in heart, liver, skeletal muscle and pancreas. At very low levels expressed in brain, placenta and lung.

Database cross-references

UniProt: Q9UBF6
Ensembl: ENST00000273480
Ensembl: ENST00000393000
Ensembl: ENST00000477012
Ensembl: ENST00000480908
MIM: 603863
neXtProt: NX_Q9UBF6
Antibodypedia: Q9UBF6 (may not find the protein thus also not any antibody)
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