RD23A_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: RAD23A
Protein names and data: RD23A_HUMAN , UV excision repair protein RAD23 homolog A; HR23A; hHR23A Lenght: 363 a.a.
Mass: 39609 Da
fasta formatted sequence
Function: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC. Involved in vpr-dependent replication of HIV-1 in non- proliferating cells and primary macrophages. Required for the association of HIV-1 vpr with the host proteasome.
Cellular location: Nucleus.

Genetic variants

Database cross-references

UniProt: P54725
Ensembl: ENST00000586534
Ensembl: ENST00000592268
MIM: 600061
neXtProt: NX_P54725
Antibodypedia: P54725 (may not find the protein thus also not any antibody)
Local full text data: click here

Users' comments

Login to add a comment.