RDH11_HUMAN

Source: PM23856902
BSc_CH
PM22954596
Marked as 'Integral membrane protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: RDH11 , ARSDR1, PSDR1 , CGI-82
Protein names and data: RDH11_HUMAN , Retinol dehydrogenase 11; 1.1.1.300 , Androgen-regulated short-chain dehydrogenase/reductase 1; HCV core-binding protein HCBP12; Prostate short-chain dehydrogenase/reductase 1; Retinal reductase 1; RalR1 Lenght: 318 a.a.
Mass: 35386 Da
fasta formatted sequence
Function: Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity towards 9-cis and all-trans-retinol. Also involved in the metabolism of short-chain aldehydes. No steroid dehydrogenase activity detected.
Catalytic activity: All-trans-retinol + NADP(+) = all-trans- retinal + NADPH.
Cellular location: Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Tissue specificity: Predominantly expressed in the epithelial cells of prostate, in both basal and luminal secretory cell populations. Expressed at low levels in spleen, thymus, testis, ovary, small intestine, colon, peripherical blood leukocytes, kidney, adrenal gland and fetal liver. Not detected in prostatic fibromuscular stromal cells, endothelial cells, or infiltrating lymphocytes.

Database cross-references

UniProt: Q8TC12
Ensembl: ENST00000381346
Ensembl: ENST00000428130
Ensembl: ENST00000553384
MIM: 607849
neXtProt: NX_Q8TC12
Antibodypedia: Q8TC12 (may not find the protein thus also not any antibody)
Local full text data: click here

Users' comments

Login to add a comment.