REN3B_HUMAN

Source: PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: UPF3B , RENT3B, UPF3X
Protein names and data: REN3B_HUMAN , Regulator of nonsense transcripts 3B , Nonsense mRNA reducing factor 3B; Up-frameshift suppressor 3 homolog B; hUpf3B; Up-frameshift suppressor 3 homolog on chromosome X; hUpf3p-X Lenght: 483 a.a.
Mass: 57762 Da
fasta formatted sequence
Function: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2- UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation; the function is independent of association with UPF2 and components of the EJC core.
Disease:
Cellular location: Nucleus. Cytoplasm. Note=Shuttling between the nucleus and the cytoplasm.
Tissue specificity: Expressed in testis, uterus, prostate, heart, muscle, brain, spinal cord and placenta.

Genetic variants

Database cross-references

UniProt: Q9BZI7
Ensembl: ENST00000276201
Ensembl: ENST00000345865
MIM: 300298
MIM: 300676
neXtProt: NX_Q9BZI7
Antibodypedia: Q9BZI7 (may not find the protein thus also not any antibody)
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