RFFL_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: RFFL , RNF189, RNF34L
Protein names and data: RFFL_HUMAN , E3 ubiquitin-protein ligase rififylin; 6.3.2.- , Caspase regulator CARP2; Caspases-8 and -10-associated RING finger protein 2; CARP-2; FYVE-RING finger protein Sakura; Fring; RING finger and FYVE-like domain-containing protein 1; RING finger protein 189; RING finger protein 34-like Lenght: 363 a.a.
Mass: 40514 Da
fasta formatted sequence
Function: Has E3 ubiquitin protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. Has anti-apoptotic activity. May bind phosphatidylinositol phosphates.
Pathway: Protein modification; protein ubiquitination.
Cellular location: Cytoplasm. Membrane; Peripheral membrane protein.
Tissue specificity: Ubiquitous. Detected in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes.

Database cross-references

UniProt: Q8WZ73
Ensembl: ENST00000268850
Ensembl: ENST00000315249
Ensembl: ENST00000378516
Ensembl: ENST00000394597
Ensembl: ENST00000413582
Ensembl: ENST00000415395
Ensembl: ENST00000447669
Ensembl: ENST00000584655
MIM: 609735
neXtProt: NX_Q8WZ73
Antibodypedia: Q8WZ73 (may not find the protein thus also not any antibody)
Local full text data: click here

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