Source: hRBCD ; ID: IPI00329565
BGMUT ; ID: rh
Marked as 'Integral membrane protein'
Confidence: high (a blood group or CD marker) Search PubMed for
(RBC AND this entry)

Gene names: RHCE , RHC, RHE
Protein names and data: RHCE_HUMAN , Blood group Rh(CE) polypeptide , Rh polypeptide 1; RhPI; Rh30A; RhIXB; Rhesus C/E antigens; CD240CE Lenght: 417 a.a.
Mass: 45560 Da
fasta formatted sequence

Function: May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane.
Cellular location: Membrane; Multi-pass membrane protein.
Tissue specificity: Restricted to tissues or cell lines expressing erythroid characters. Isoform 4g and isoform RhPI-Alpha are expressed in immature erythroblasts but not in mature erythroblasts.

Genetic variants

RhCE and RhD are responsible for the RH blood group system. The molecular basis of the E=Rh3/e=Rh5 blood group antigens is a single variation in position 226; Pro-226 corresponds to Rh3 and Ala-226 to Rh5. The molecular basis of the C=Rh2/c=Rh4 blood group antigens is a single variation in position 102; Ser-103 corresponds to Rh2 and Pro-103 to Rh4.

Database cross-references

UniProt: P18577
Ensembl: ENST00000294413
MIM: 111690
MIM: 111700
neXtProt: NX_P18577
Antibodypedia: P18577 (may not find the protein thus also not any antibody)
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