RHG17_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: ARHGAP17 , RICH1 , MSTP066, MSTP110
Protein names and data: RHG17_HUMAN , Rho GTPase-activating protein 17 , Rho-type GTPase-activating protein 17; RhoGAP interacting with CIP4 homologs protein 1; RICH-1 Lenght: 881 a.a.
Mass: 95437 Da
fasta formatted sequence
Function: Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1.
Cellular location: Membrane; Peripheral membrane protein. Cytoplasm. Cell junction, tight junction. Note=Associates with membranes and concentrates at sites of cell-cell contact.
Tissue specificity: Ubiquitously expressed. Expressed at higher level in heart and placenta.

Database cross-references

UniProt: Q68EM7
Ensembl: ENST00000289968
Ensembl: ENST00000303665
Ensembl: ENST00000441763
MIM: 608293
neXtProt: NX_Q68EM7
Antibodypedia: Q68EM7 (may not find the protein thus also not any antibody)
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