RHOB_HUMAN

Source: PM19886704
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: RHOB , ARH6, ARHB
Protein names and data: RHOB_HUMAN , Rho-related GTP-binding protein RhoB , Rho cDNA clone 6; h6; Flags: Precursor Lenght: 196 a.a.
Mass: 22123 Da
fasta formatted sequence
Function: Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells.
Cellular location: Late endosome membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Nucleus. Cleavage furrow. Note=Late endosomal membrane (geranylgeranylated form). Plasma membrane (farnesylated form). Also detected at the nuclear margin and in the nucleus. Translocates to the equatorial region before furrow formation in a ECT2-dependent manner.

Database cross-references

UniProt: P62745
Ensembl: ENST00000272233
MIM: 165370
neXtProt: NX_P62745
Antibodypedia: P62745 (may not find the protein thus also not any antibody)
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