RIC8A_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: RIC8A
Protein names and data: RIC8A_HUMAN , Synembryn-A , Protein Ric-8A Lenght: 531 a.a.
Mass: 59710 Da
fasta formatted sequence
Function: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.
Cellular location: Cytoplasm (By similarity). Cell membrane (By similarity). Note=Colocalizes with RIC8A in CA2 hippocampal neurons. Colocalizes with GNAI1 and RGS14 at the plasma membrane (By similarity).

Database cross-references

UniProt: Q9NPQ8
Ensembl: ENST00000325207
Ensembl: ENST00000526104
Ensembl: ENST00000527696
MIM: 609146
neXtProt: NX_Q9NPQ8
Antibodypedia: Q9NPQ8 (may not find the protein thus also not any antibody)
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