RILP_HUMAN

Source: PM19886704
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: RILP , PP10141
Protein names and data: RILP_HUMAN , Rab-interacting lysosomal protein Lenght: 401 a.a.
Mass: 44200 Da
fasta formatted sequence
Function: Rab effector playing a role in late endocytic transport to degradative compartments. Involved in the regulation of lysosomal morphology and distribution. Induces recruitment of dynein-dynactin motor complexes to Rab7A-containing late endosome and lysosome compartments. Promotes centripetal migration of phagosomes and the fusion of phagosomes with the late endosomes and lysosomes.
Cellular location: Endomembrane system. Late endosome membrane. Lysosome membrane. Cytoplasmic vesicle, phagosome membrane. Note=Associated with late endosomal, lysosomal and phagosomal membranes. The interaction with RAB7A is necessary for its recruitment to phagosomes.
Tissue specificity: Ubiquitous. Strongly expressed in fetal heart, heart, stomach, spleen, adrenal gland, thyroid gland, salivary gland, fetal liver, liver and lung. Poorly expressed in brain.

Genetic variants

Database cross-references

UniProt: Q96NA2
Ensembl: ENST00000301336
MIM: 607848
neXtProt: NX_Q96NA2
Antibodypedia: Q96NA2 (may not find the protein thus also not any antibody)
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