RL13A_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: RPL13A
Protein names and data: RL13A_HUMAN , 60S ribosomal protein L13a , 23 kDa highly basic protein Lenght: 203 a.a.
Mass: 23577 Da
fasta formatted sequence
Function: Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex. Involved in methylation of rRNA.
Cellular location: Cytoplasm (Probable).

Database cross-references

UniProt: P40429
Ensembl: ENST00000391857
neXtProt: NX_P40429
Antibodypedia: P40429 (may not find the protein thus also not any antibody)
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