RBCC Red Blood Cell Collection

RN123_HUMAN

Source: hRBCD ; ID: IPI00335085
PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: RNF123 , KPC1 , FP1477
Protein names and data: RN123_HUMAN , E3 ubiquitin-protein ligase RNF123; 6.3.2.- , Kip1 ubiquitination-promoting complex protein 1; RING finger protein 123 Lenght: 1314 a.a.
Mass: 148515 Da
fasta formatted sequence
Function: Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle.
Pathway: Protein modification; protein ubiquitination.
Cellular location: Cytoplasm.

Genetic variants

51 - 51 P -> R (in dbSNP:rs2960546). VAR_027561 2960546
387 - 387 R -> Q (in dbSNP:rs35620248). VAR_052106 35620248
596 - 596 K -> E (in dbSNP:rs35726701). VAR_052107 35726701
854 - 854 R -> H (in dbSNP:rs34823813). VAR_052108 34823813

Database cross-references

UniProt: Q5XPI4
Ensembl: ENST00000327697
MIM: 614472
neXtProt: NX_Q5XPI4
Antibodypedia: Q5XPI4 (may not find the protein thus also not any antibody)
Local full text data: click here

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