RNAS2_HUMAN

Source: BSc_CH
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: RNASE2 , EDN, RNS2
Protein names and data: RNAS2_HUMAN , Non-secretory ribonuclease; 3.1.27.5 , Eosinophil-derived neurotoxin; RNase UpI-2; Ribonuclease 2; RNase 2; Ribonuclease US; Flags: Precursor Lenght: 161 a.a.
Mass: 18354 Da
fasta formatted sequence
Function: This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Selectively chemotactic for dendritic cells. Possesses a wide variety of biological activities.
Catalytic activity: Endonucleolytic cleavage to nucleoside 3'- phosphates and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates.
Cellular location: Lysosome (Probable). Cytoplasmic granule. Note=Matrix of eosinophil's large specific granule.
Tissue specificity: Liver, lung, spleen, leukocytes and body fluids.

Genetic variants

Database cross-references

UniProt: P10153
Ensembl: ENST00000304625
MIM: 131410
neXtProt: NX_P10153
Antibodypedia: P10153 (may not find the protein thus also not any antibody)
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