RPB4_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: POLR2D
Protein names and data: RPB4_HUMAN , DNA-directed RNA polymerase II subunit RPB4; RNA polymerase II subunit B4 , DNA-directed RNA polymerase II subunit D; RNA polymerase II 16 kDa subunit; RPB16 Lenght: 142 a.a.
Mass: 16311 Da
fasta formatted sequence
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB4 is part of a subcomplex with RPB7 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity).
Cellular location: Nucleus.

Database cross-references

UniProt: O15514
Ensembl: ENST00000272645
MIM: 606017
neXtProt: NX_O15514
Antibodypedia: O15514 (may not find the protein thus also not any antibody)
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