RPB7_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: POLR2G , RPB7
Protein names and data: RPB7_HUMAN , DNA-directed RNA polymerase II subunit RPB7; RNA polymerase II subunit B7 , DNA-directed RNA polymerase II subunit G; RNA polymerase II 19 kDa subunit; RPB19 Lenght: 172 a.a.
Mass: 19294 Da
fasta formatted sequence
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity). Binds RNA.
Cellular location: Nucleus.

Database cross-references

UniProt: P62487
Ensembl: ENST00000301788
MIM: 602013
neXtProt: NX_P62487
Antibodypedia: P62487 (may not find the protein thus also not any antibody)
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