RPN1_HUMAN

Source: BSc_CH
Marked as 'Integral membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: RPN1
Protein names and data: RPN1_HUMAN , Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; 2.4.99.18 , Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit; Ribophorin I; RPN-I; Ribophorin-1; Flags: Precursor Lenght: 607 a.a.
Mass: 68569 Da
fasta formatted sequence
Function: Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains.
Catalytic activity: Dolichyl diphosphooligosaccharide + [protein]- L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine.
Pathway: Protein modification; protein glycosylation.
Cellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Tissue specificity: Expressed in all tissues tested.

Database cross-references

UniProt: P04843
Ensembl: ENST00000296255
MIM: 180470
neXtProt: NX_P04843
Antibodypedia: P04843 (may not find the protein thus also not any antibody)
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