RPR1B_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: RPRD1B , C20orf77, CREPT
Protein names and data: RPR1B_HUMAN , Regulation of nuclear pre-mRNA domain-containing protein 1B , Cell cycle-related and expression-elevated protein in tumor Lenght: 326 a.a.
Mass: 36900 Da
fasta formatted sequence
Function: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation.
Cellular location: Nucleus.
Tissue specificity: Preferentially expressed in a range of tumor tissues including colon, lung, liver, breast, prostate, stomach, uterine endometrium and cervical cancers with higher levels in tumors than in adjacent non-tumor tissue (at protein level).

Database cross-references

UniProt: Q9NQG5
Ensembl: ENST00000373433
MIM: 614694
neXtProt: NX_Q9NQG5
Antibodypedia: Q9NQG5 (may not find the protein thus also not any antibody)
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