RS27A_HUMAN

Source: hRBCD ; ID: IPI00179330
PM23856902
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: RPS27A , UBA80, UBCEP1
Protein names and data: RS27A_HUMAN , Ubiquitin-40S ribosomal protein S27a , Ubiquitin carboxyl extension protein 80; Ubiquitin; 40S ribosomal protein S27a; Flags: Precursor Lenght: 156 a.a.
Mass: 17965 Da
fasta formatted sequence
Function: Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. Ribosomal protein S27a is a component of the 40S subunit of the ribosome.
Cellular location: Ubiquitin: Cytoplasm (By similarity). Nucleus (By similarity).

Database cross-references

UniProt: P62979
Ensembl: ENST00000272317
Ensembl: ENST00000402285
Ensembl: ENST00000404735
MIM: 191343
neXtProt: NX_P62979
Antibodypedia: P62979 (may not find the protein thus also not any antibody)
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