RTCA_HUMAN

Source: PM19886704
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: RTCA , RPC, RPC1, RTC1, RTCD1
Protein names and data: RTCA_HUMAN , RNA 3'-terminal phosphate cyclase; RNA cyclase; RNA-3'-phosphate cyclase; 6.5.1.4 , RNA terminal phosphate cyclase domain-containing protein 1; RTC domain-containing protein 1 Lenght: 366 a.a.
Mass: 39337 Da
fasta formatted sequence
Function: Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA- N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'- phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Catalytic activity: ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate.
Cellular location: Nucleus, nucleoplasm.
Tissue specificity: Ubiquitous.

Database cross-references

UniProt: O00442
Ensembl: ENST00000260563
Ensembl: ENST00000370128
MIM: 611286
neXtProt: NX_O00442
Antibodypedia: O00442 (may not find the protein thus also not any antibody)
Local full text data: click here

Users' comments

Login to add a comment.