Source: hRBCD ; ID: IPI00028946
Marked as 'Integral membrane protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)

Gene names: RTN3 , ASYIP, NSPL2
Protein names and data: RTN3_HUMAN , Reticulon-3 , Homolog of ASY protein; HAP; Neuroendocrine-specific protein-like 2; NSP-like protein 2; Neuroendocrine-specific protein-like II; NSP-like protein II; NSPLII Lenght: 1032 a.a.
Mass: 112611 Da
fasta formatted sequence

Function: May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. In case of enteroviruses infection, RTN3 may be involved in the viral replication or pathogenesis.
Cellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Tissue specificity: Isoform 3 is widely expressed, with highest levels in brain, where it is enriched in neuronal cell bodies from gray matter (at protein level). Three times more abundant in macula than in peripheral retina. Isoform 1 is expressed at high levels in brain and at low levels in skeletal muscle. Isoform 2 is only found in melanoma.

Genetic variants

Database cross-references

UniProt: O95197
Ensembl: ENST00000339997
Ensembl: ENST00000341307
Ensembl: ENST00000354497
Ensembl: ENST00000356000
Ensembl: ENST00000377819
Ensembl: ENST00000537981
Ensembl: ENST00000540798
MIM: 604249
neXtProt: NX_O95197
Antibodypedia: O95197 (may not find the protein thus also not any antibody)
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