Source: PM23856902
Marked as 'Integral membrane protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)

Gene names: RTN4 , KIAA0886, NOGO , My043, SP1507
Protein names and data: RTN4_HUMAN , Reticulon-4 , Foocen; Neurite outgrowth inhibitor; Nogo protein; Neuroendocrine-specific protein; NSP; Neuroendocrine-specific protein C homolog; RTN-x; Reticulon-5 Lenght: 1192 a.a.
Mass: 129931 Da
fasta formatted sequence

Function: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing.
Cellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Anchored to the membrane of the endoplasmic reticulum through 2 putative transmembrane domains.
Tissue specificity: Isoform 1 is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform 2 is widely expressed except for the liver. Isoform 3 is expressed in brain, skeletal muscle and adipocytes. Isoform 4 is testis- specific.

Genetic variants

Database cross-references

UniProt: Q9NQC3
Ensembl: ENST00000317610
Ensembl: ENST00000337526
Ensembl: ENST00000357376
Ensembl: ENST00000357732
Ensembl: ENST00000394609
Ensembl: ENST00000394611
Ensembl: ENST00000404909
Ensembl: ENST00000405240
MIM: 604475
neXtProt: NX_Q9NQC3
Antibodypedia: Q9NQC3 (may not find the protein thus also not any antibody)
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