S12A7_HUMAN

Source: hRBCD ; ID: IPI00008616
PM19886704
PM23856902
BSc_CH
PM22954596
Marked as 'Integral membrane protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: SLC12A7 , KCC4
Protein names and data: S12A7_HUMAN , Solute carrier family 12 member 7 , Electroneutral potassium-chloride cotransporter 4; K-Cl cotransporter 4 Lenght: 1083 a.a.
Mass: 119106 Da
fasta formatted sequence
Function: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity).
Cellular location: Cell membrane; Multi-pass membrane protein.
Tissue specificity: Detected in muscle, brain, lung, heart and kidney.

Genetic variants

Database cross-references

UniProt: Q9Y666
Ensembl: ENST00000264930
MIM: 604879
neXtProt: NX_Q9Y666
Antibodypedia: Q9Y666 (may not find the protein thus also not any antibody)
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