S14L2_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: SEC14L2 , C22orf6, KIAA1186, KIAA1658
Protein names and data: S14L2_HUMAN , SEC14-like protein 2 , Alpha-tocopherol-associated protein; TAP; hTAP; Squalene transfer protein; Supernatant protein factor; SPF Lenght: 403 a.a.
Mass: 46145 Da
fasta formatted sequence
Function: Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell.
Cellular location: Cytoplasm. Nucleus. Note=Cytoplasmic in absence of alpha-tocopherol, and nuclear in presence of alpha- tocopherol.
Tissue specificity: Widely expressed. Strong expression in liver, brain and prostate.

Genetic variants

Database cross-references

UniProt: O76054
Ensembl: ENST00000312932
Ensembl: ENST00000402592
Ensembl: ENST00000405717
MIM: 607558
neXtProt: NX_O76054
Antibodypedia: O76054 (may not find the protein thus also not any antibody)
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