SAHH_HUMAN

Source: hRBCD ; ID: IPI00012007
PM19886704
PM23856902
PM22954596
Marked as 'Non-membrane protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: AHCY , SAHH
Protein names and data: SAHH_HUMAN , Adenosylhomocysteinase; AdoHcyase; 3.3.1.1 , S-adenosyl-L-homocysteine hydrolase Lenght: 432 a.a.
Mass: 47716 Da
fasta formatted sequence
Function: Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.
Catalytic activity: S-adenosyl-L-homocysteine + H(2)O = L- homocysteine + adenosine.
Pathway: Amino-acid biosynthesis; L-homocysteine biosynthesis; L- homocysteine from S-adenosyl-L-homocysteine: step 1/1.
Disease:
Cellular location: Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Genetic variants

Database cross-references

UniProt: P23526
Ensembl: ENST00000217426
Ensembl: ENST00000538132
MIM: 180960
MIM: 613752
neXtProt: NX_P23526
Antibodypedia: P23526 (may not find the protein thus also not any antibody)
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