SDCB1_HUMAN

Source: PM23856902
BSc_CH
Marked as 'Integral membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: SDCBP , MDA9, SYCL
Protein names and data: SDCB1_HUMAN , Syntenin-1 , Melanoma differentiation-associated protein 9; MDA-9; Pro-TGF-alpha cytoplasmic domain-interacting protein 18; TACIP18; Scaffold protein Pbp1; Syndecan-binding protein 1 Lenght: 298 a.a.
Mass: 32444 Da
fasta formatted sequence
Function: Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway.
Cellular location: Cell junction, focal adhesion. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Nucleus. Melanosome. Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Note=Mainly membrane-associated. Localized to adherens junctions, focal adhesions and endoplasmic reticulum. Colocalized with actin stress fibers. Also found in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Tissue specificity: Widely expressed. Expressed in fetal kidney, liver, lung and brain. In adult highest expression in heart and placenta.

Genetic variants

Database cross-references

UniProt: O00560
Ensembl: ENST00000260130
Ensembl: ENST00000413219
Ensembl: ENST00000422546
Ensembl: ENST00000424270
Ensembl: ENST00000447182
MIM: 602217
neXtProt: NX_O00560
Antibodypedia: O00560 (may not find the protein thus also not any antibody)
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