SENP8_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: SENP8 , DEN1, NEDP1, PRSC2 , FKSG8
Protein names and data: SENP8_HUMAN , Sentrin-specific protease 8; 3.4.22.68 , Deneddylase-1; NEDD8-specific protease 1; Protease, cysteine 2; Sentrin/SUMO-specific protease SENP8 Lenght: 212 a.a.
Mass: 24107 Da
fasta formatted sequence
Function: Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53.
Catalytic activity: Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly-|-Ala-Thr-Tyr at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein.
Tissue specificity: Broadly expressed, with highest levels in kidney and pancreas.

Genetic variants

Database cross-references

UniProt: Q96LD8
Ensembl: ENST00000340912
Ensembl: ENST00000542035
Ensembl: ENST00000544171
Ensembl: ENST00000544411
MIM: 608659
neXtProt: NX_Q96LD8
Antibodypedia: Q96LD8 (may not find the protein thus also not any antibody)
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