SIAS_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: NANS , SAS
Protein names and data: SIAS_HUMAN , Sialic acid synthase , N-acetylneuraminate synthase; 2.5.1.56; N-acetylneuraminate-9-phosphate synthase; 2.5.1.57; N-acetylneuraminic acid phosphate synthase; N-acetylneuraminic acid synthase Lenght: 359 a.a.
Mass: 40308 Da
fasta formatted sequence
Function: Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3- deoxy-D-glycero-D-galacto-nononic acid (KDN). Can also use N- acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively.
Catalytic activity: Phosphoenolpyruvate + N-acetyl-D-mannosamine + H(2)O = phosphate + N-acetylneuraminate. Phosphoenolpyruvate + N-acyl-D-mannosamine 6- phosphate + H(2)O = N-acylneuraminate 9-phosphate + phosphate.
Tissue specificity: Ubiquitous.

Genetic variants

Database cross-references

UniProt: Q9NR45
Ensembl: ENST00000210444
MIM: 605202
neXtProt: NX_Q9NR45
Antibodypedia: Q9NR45 (may not find the protein thus also not any antibody)
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