SIN1_HUMAN

Source: PM19886704
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: MAPKAP1 , MIP1, SIN1
Protein names and data: SIN1_HUMAN , Target of rapamycin complex 2 subunit MAPKAP1; TORC2 subunit MAPKAP1 , Mitogen-activated protein kinase 2-associated protein 1; Stress-activated map kinase-interacting protein 1; SAPK-interacting protein 1; mSIN1 Lenght: 522 a.a.
Mass: 59123 Da
fasta formatted sequence
Function: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex.
Cellular location: Cell membrane; Peripheral membrane protein. Cytoplasmic vesicle. Nucleus.
Tissue specificity: Ubiquitously expressed, with highest levels in heart and skeletal muscle.

Database cross-references

UniProt: Q9BPZ7
Ensembl: ENST00000265960
Ensembl: ENST00000350766
Ensembl: ENST00000373498
Ensembl: ENST00000373503
Ensembl: ENST00000373511
Ensembl: ENST00000394060
Ensembl: ENST00000394063
MIM: 610558
neXtProt: NX_Q9BPZ7
Antibodypedia: Q9BPZ7 (may not find the protein thus also not any antibody)
Local full text data: click here

Users' comments

Login to add a comment.