SIR2_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: SIRT2 , SIR2L, SIR2L2
Protein names and data: SIR2_HUMAN , NAD-dependent protein deacetylase sirtuin-2; 3.5.1.- , Regulatory protein SIR2 homolog 2; SIR2-like protein 2 Lenght: 389 a.a.
Mass: 43182 Da
fasta formatted sequence
Function: NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and non-histone proteins such as ACLY, PCK1 and RELA. Deacetylates 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Deacetylates PCK1, opposing proteasomal degradation. Deacetylates 'Lys-310' of RELA.
Catalytic activity: NAD(+) + an acetylprotein = nicotinamide + O- acetyl-ADP-ribose + a protein.
Cellular location: Cytoplasm, cytoskeleton. Note=Colocalizes with microtubules.
Tissue specificity: Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulation of microtubule network.

Database cross-references

UniProt: Q8IXJ6
Ensembl: ENST00000249396
Ensembl: ENST00000358931
Ensembl: ENST00000392081
MIM: 604480
neXtProt: NX_Q8IXJ6
Antibodypedia: Q8IXJ6 (may not find the protein thus also not any antibody)
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