SIR5_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: SIRT5 , SIR2L5
Protein names and data: SIR5_HUMAN , NAD-dependent protein deacylase sirtuin-5, mitochondrial; 3.5.1.- , Regulatory protein SIR2 homolog 5; SIR2-like protein 5; Flags: Precursor Lenght: 310 a.a.
Mass: 33881 Da
fasta formatted sequence
Function: NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro.
Catalytic activity: NAD(+) + a malonylprotein = nicotinamide + O- malonyl-ADP-ribose + a protein. NAD(+) + a succinylprotein = nicotinamide + O- succinyl-ADP-ribose + a protein.
Cellular location: Mitochondrion matrix. Mitochondrion intermembrane space. Cytoplasm, cytosol. Nucleus. Note=Mainly mitochondrial. Also present extramitochondrially: a fraction is present in the cytosol and very small amounts are also detected in the nucleus. Isoform 1: Cytoplasm. Mitochondrion. Isoform 2: Mitochondrion.
Tissue specificity: Widely expressed.

Genetic variants

Database cross-references

UniProt: Q9NXA8
Ensembl: ENST00000359782
Ensembl: ENST00000379262
Ensembl: ENST00000397350
Ensembl: ENST00000606117
MIM: 604483
neXtProt: NX_Q9NXA8
Antibodypedia: Q9NXA8 (may not find the protein thus also not any antibody)
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