SL9A3_HUMAN

Source: PM19886704
PM23856902
Marked as 'Integral membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: SLC9A3 , NHE3
Protein names and data: SL9A3_HUMAN , Sodium/hydrogen exchanger 3 , Na(+)/H(+) exchanger 3; NHE-3; Solute carrier family 9 member 3 Lenght: 834 a.a.
Mass: 92855 Da
fasta formatted sequence
Function: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.
Cellular location: Apical cell membrane; Multi-pass membrane protein. Note=In intestinal epithelial cells, localizes to the ileal brush border. Phosphorylation at Ser-663 by SGK1 is associated with increased abundance at the cell membrane.

Genetic variants

Database cross-references

UniProt: P48764
Ensembl: ENST00000264938
MIM: 182307
neXtProt: NX_P48764
Antibodypedia: P48764 (may not find the protein thus also not any antibody)
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