SMAD2_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: SMAD2 , MADH2, MADR2
Protein names and data: SMAD2_HUMAN , Mothers against decapentaplegic homolog 2; MAD homolog 2; Mothers against DPP homolog 2 , JV18-1; Mad-related protein 2; hMAD-2; SMAD family member 2; SMAD 2; Smad2; hSMAD2 Lenght: 467 a.a.
Mass: 52306 Da
fasta formatted sequence
Function: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Cellular location: Cytoplasm. Nucleus. Note=Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4. On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1.
Tissue specificity: Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta.

Genetic variants

Database cross-references

UniProt: Q15796
Ensembl: ENST00000262160
Ensembl: ENST00000356825
Ensembl: ENST00000402690
Ensembl: ENST00000586040
MIM: 601366
neXtProt: NX_Q15796
Antibodypedia: Q15796 (may not find the protein thus also not any antibody)
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