SMC2_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: SMC2 , CAPE, SMC2L1 , PRO0324
Protein names and data: SMC2_HUMAN , Structural maintenance of chromosomes protein 2; SMC protein 2; SMC-2 , Chromosome-associated protein E; hCAP-E; XCAP-E homolog Lenght: 1197 a.a.
Mass: 135656 Da
fasta formatted sequence
Function: Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
Cellular location: Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.

Genetic variants

Database cross-references

UniProt: O95347
Ensembl: ENST00000286398
Ensembl: ENST00000303219
Ensembl: ENST00000374787
Ensembl: ENST00000374793
Ensembl: ENST00000493955
MIM: 605576
neXtProt: NX_O95347
Antibodypedia: O95347 (may not find the protein thus also not any antibody)
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