SMC4_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: SMC4 , CAPC, SMC4L1
Protein names and data: SMC4_HUMAN , Structural maintenance of chromosomes protein 4; SMC protein 4; SMC-4 , Chromosome-associated polypeptide C; hCAP-C; XCAP-C homolog Lenght: 1288 a.a.
Mass: 147182 Da
fasta formatted sequence
Function: Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
Cellular location: Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
Tissue specificity: Widely expressed. Higher expression in testis, colon, thymus.

Genetic variants

Database cross-references

UniProt: Q9NTJ3
Ensembl: ENST00000344722
Ensembl: ENST00000357388
Ensembl: ENST00000360111
Ensembl: ENST00000462787
MIM: 605575
neXtProt: NX_Q9NTJ3
Antibodypedia: Q9NTJ3 (may not find the protein thus also not any antibody)
Local full text data: click here

Users' comments

Login to add a comment.