Source: PM19886704
Marked as 'Membrane associated protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)

Gene names: SNF8 , EAP30
Protein names and data: SNF8_HUMAN , Vacuolar-sorting protein SNF8 , ELL-associated protein of 30 kDa; ESCRT-II complex subunit VPS22; hVps22 Lenght: 258 a.a.
Mass: 28864 Da
fasta formatted sequence

Function: Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4.
Cellular location: Cytoplasm. Endosome membrane. Nucleus (Probable). Late endosome membrane. Note=Recruited to the endosome membrane to participate in vesicle formation.

Database cross-references

UniProt: Q96H20
Ensembl: ENST00000290330
Ensembl: ENST00000502492
MIM: 610904
neXtProt: NX_Q96H20
Antibodypedia: Q96H20 (may not find the protein thus also not any antibody)
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