SNX1_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: SNX1
Protein names and data: SNX1_HUMAN , Sorting nexin-1 Lenght: 522 a.a.
Mass: 59070 Da
fasta formatted sequence
Function: May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3- phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).
Cellular location: Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Enriched on tubular elements of the early endosome membrane. Binds preferentially to highly curved membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).

Genetic variants

Database cross-references

UniProt: Q13596
Ensembl: ENST00000261889
Ensembl: ENST00000559844
Ensembl: ENST00000561026
MIM: 601272
neXtProt: NX_Q13596
Antibodypedia: Q13596 (may not find the protein thus also not any antibody)
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