SPB3_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: SERPINB3 , SCCA, SCCA1
Protein names and data: SPB3_HUMAN , Serpin B3 , Protein T4-A; Squamous cell carcinoma antigen 1; SCCA-1 Lenght: 390 a.a.
Mass: 44565 Da
fasta formatted sequence
Function: May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1).
Cellular location: Cytoplasm. Note=Seems to also be secreted in plasma by cancerous cells but at a low level.
Tissue specificity: Squamous cells. Expressed in some hepatocellular carcinoma (at protein level).

Genetic variants

Database cross-references

UniProt: P29508
Ensembl: ENST00000283752
Ensembl: ENST00000332821
MIM: 600517
neXtProt: NX_P29508
Antibodypedia: P29508 (may not find the protein thus also not any antibody)
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