SPCS_HUMAN

Source: PM23856902
PM22954596
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: SEPSECS , TRNP48
Protein names and data: SPCS_HUMAN , O-phosphoseryl-tRNA(Sec) selenium transferase; 2.9.1.2 , Liver-pancreas antigen; LP; SLA-p35; SLA/LP autoantigen; Selenocysteine synthase; Sec synthase; Selenocysteinyl-tRNA(Sec) synthase; Sep-tRNA:Sec-tRNA synthase; SepSecS; Soluble liver antigen; SLA; UGA suppressor tRNA-associated protein; tRNA(Ser/Sec)-associated antigenic protein Lenght: 501 a.a.
Mass: 55726 Da
fasta formatted sequence
Function: Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis.
Catalytic activity: O-phospho-L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + phosphate.
Pathway: Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (archaeal/eukaryal route): step 2/2.
Disease:
Cellular location: Cytoplasm.
Tissue specificity: Primarily expressed in liver, pancreas, kidney and lung. Overexpressed in PHA-stimulated T-cells.

Genetic variants

Database cross-references

UniProt: Q9HD40
Ensembl: ENST00000302922
Ensembl: ENST00000382103
Ensembl: ENST00000514585
MIM: 613009
MIM: 613811
neXtProt: NX_Q9HD40
Antibodypedia: Q9HD40 (may not find the protein thus also not any antibody)
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