Source: BSc_CH
Marked as 'Integral membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)

Gene names: SPTLC1 , LCB1
Protein names and data: SPTC1_HUMAN , Serine palmitoyltransferase 1; , Long chain base biosynthesis protein 1; LCB 1; Serine-palmitoyl-CoA transferase 1; SPT 1; SPT1 Lenght: 473 a.a.
Mass: 52744 Da
fasta formatted sequence

Function: Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1- SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference.
Catalytic activity: Palmitoyl-CoA + L-serine = CoA + 3-dehydro-D- sphinganine + CO(2).
Pathway: Lipid metabolism; sphingolipid metabolism.
Cellular location: Endoplasmic reticulum membrane; Single-pass membrane protein (By similarity).
Tissue specificity: Widely expressed. Not detected in small intestine.

Genetic variants

Database cross-references

UniProt: O15269
Ensembl: ENST00000262554
Ensembl: ENST00000337841
MIM: 162400
MIM: 605712
neXtProt: NX_O15269
Antibodypedia: O15269 (may not find the protein thus also not any antibody)
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