SRBP1_HUMAN
Source: PM19886704PM23856902
Marked as 'Integral membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: SREBF1 , BHLHD1, SREBP1
Protein names and data: SRBP1_HUMAN , Sterol regulatory element-binding protein 1; SREBP-1 , Class D basic helix-loop-helix protein 1; bHLHd1; Sterol regulatory element-binding transcription factor 1; Processed sterol regulatory element-binding protein 1 Lenght: 1147 a.a.
Mass: 121675 Da
fasta formatted sequence
Function: Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3').
Cellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols. Processed sterol regulatory element-binding protein 1: Nucleus. Isoform SREBP-1aDelta: Nucleus. Isoform SREBP-1cDelta: Nucleus.
Tissue specificity: Expressed in a wide variety of tissues, most abundant in liver and adrenal gland. In fetal tissues lung and liver shows highest expression. Isoform SREBP-1C predominates in liver, adrenal gland and ovary, whereas isoform SREBP-1A predominates in hepatoma cell lines. Isoform SREBP-1A and isoform SREBP-1C are found in kidney, brain, white fat, and muscle.
Genetic variants
Database cross-references
UniProt: P36956Ensembl: ENST00000261646
Ensembl: ENST00000338854
Ensembl: ENST00000355815
Ensembl: ENST00000435530
MIM: 184756
neXtProt: NX_P36956
Antibodypedia: P36956 (may not find the protein thus also not any antibody)
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